The evidence is strong. Multiple placebo-controlled RCTs show meaningful improvements in skin elasticity, hydration, and wrinkle depth at 2.5–10g per day over 8–12 weeks. Separate trials show reductions in joint pain and improved function in both athletes and adults with knee discomfort. At 20g per puck, Crema meets or exceeds every clinically studied dose.
Research: Proksch et al., Skin Pharmacol Physiol 2014 · Zdzieblik et al., Appl Physiol Nutr Metab 2017 · Clark et al., Curr Med Res Opin 2008.
†These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.